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President Obama departed Washington on Thursday for a two-day trip that will give him a chance to enroll America’s southern neighbors in the push for immigration reform.

The agenda for Obama’s trip, which will begin on Thursday afternoon in Mexico, is likely to be dominated by immigration, a top concern of countries that have seen an exodus of citizens to the United States.

Ben Rhodes, the president’s deputy national security adviser for strategic communications, said immigration would be front and center during Obama’s visit.