Deal breaks a promise made to taxpayers in 2011 to curtail spending.
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The Senate voted 67-33 Tuesday to advance the Ryan-Murray budget compromise that conservatives oppose as fiscally irresponsible.
Helping Democrats get the votes they needed, 12 Republicans voted with all 55 Democrats to begin debate on the measure.
Republicans joining Democrats to invoke cloture include Lamar Alexander (Tenn.), Roy Blunt (Mo.), Saxby Chambliss (Ga.), Susan Collins (Maine), Jeff Flake (Ariz.), Orrin Hatch (Utah), John Hoeven (N.D.), Johnny Isakson (Ga.), Ron Johnson (Wis.), John McCain (Ariz.), Lisa Murkowski (Alaska), and Rob Portman (Ohio).