Tragic for anyone.
Check it out:

He was the privileged son of a longtime U.S. senator and two-term vice president, yet Joseph R. “Beau” Biden III was no stranger to personal adversity.

When he was only 3, just weeks after his father, Joe Biden, had been elected to the Senate, the younger Biden was seriously injured in a 1972 car crash that killed his mother and infant sister. His father was sworn into office at his hospital bedside.