The battle lines were drawn on Thursday in the first major fight of the 2012 general election campaign – whether Mitt Romney or Barack Obama cares more about women’s concerns.

And Romney’s wife, Ann was right in the forefront as she hit back strongly at a Democratic strategist’s claim that she has “never worked a day in her life.”

Hilary Rosen made the accusation during a CNN interview with Anderson Cooper in which she criticized the prominent role Ann Romney is playing advising her husband on women’s issues during his campaign for the White House.

But mother-of-five Romney showed she is a force to be reckoned with in a Fox News interview on Thursday. “She should have come to my house when those five boys were causing so much trouble,” she told Martha MacCallum. “It wasn’t so easy.”

Josh Romney, the Romney’s third son also chimed in with a Twitter message supporting his mother, calling her, “one of the smartest, hardest working women I know,” adding, “Could have done anything with her life, chose to raise me.”